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pentobarbital will reduce the extent or influence of buprenorphine, extended-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Sufferers who transfer to buprenorphine long-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers must be monitored to make sure bupren